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Cell Sci. 117, 1291–1300 (2004). 73. , Ellson, C. & Hawkins, P. Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr. Opin. Cell Biol. 14, 203–213 (2002). 74. Weiner, O. D. Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr. Opin. Cell Biol. 14, 196–202 (2002). 75. Williams, M. , Wiklund, M. , Wikman, S. & Hultmark, D. Rac1 signalling in the Drosophila larval cellular immune response. J. Cell Sci. 119, 2015–2024 (2006). 76. Fessler, J. H. & Fessler, L.

Recently, Huelsmann and colleagues identified the D. melanogaster PDZ guanine-nucleotide exchange factor (PDZ-GEF) Dizzy as an essential component for normal haemocyte migration in the embryo70. In dizzy mutants, haemocytes have smaller actin protrusions and their migration is significantly slowed, whereas overexpression of Dizzy in haemocytes produces cells with vastly extended protrusions70. Dizzy is thought to operate as a GEF for the Ras superfamily member of small GTPases, Rap1 (also known as Roughened), and thereby regulate integrin-dependent adhesion in haemocytes and stabilize cellular protrusions during migrations throughout the embryo70.

The normally occurring form of the mature PRNP gene product, the presence of which is necessary, but not sufficient, for replication of the prion. Prion strain A TSE isolate (or source of infection) that, upon inoculation into genetically identical hosts, causes prion disease with consistent characteristics. The agentspecified information in prion strains is thought to be contained in the distinct conformations of various PrPSc isotypes. Horizontal prion transmission The spread of disease between individuals in a certain population or flock of animals.

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