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By Golder Wilson

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Which of the following represents your correct advice concerning the newborn child? a. b. c. d. e. A 1/8 risk for albinism and skin cancer from DNA deletions A 1/8 risk for albinism and skin cancer from DNA cross-linkage A 1/4 risk for albinism and skin cancer from DNA point mutations A 1/4 risk for albinism and skin cancer from DNA deletions A 1/4 risk for albinism and skin cancer from DNA cross-linkage 17. A culture of bacteria not resistant to tetracycline develops an infection from a virus that is derived from the lysis of tetracycline-resistant bacteria.

Scriver, pp 5587–5628. Sack, pp 3–29. ) Normal parents having two affected children, male and female, is suggestive of autosomal recessive inheritance. qxd 11/14/01 10:36 AM Page 29 DNA Structure, Replication, and Repair Answers 29 interpretation fits with the usual inheritance of oculocutaneous albinism (203100), implying a 1/4 risk for a newborn in whom signs and symptoms of albinism are not yet evident. The defect in melanin synthesis in albinism decreases the amount of this protective pigment in skin and increases the exposure of DNA in skin cells to sunlight.

Murray, pp 412–434. Scriver, pp 3–45. Sack, pp 3–29. ) The Ames test is a rapid and relatively inexpensive bacterial assay for determining mutagenicity of potential toxic chemicals. Since many chemical carcinogens are mutagenic, it seems obvious that damage to DNA is a central event in carcinogenesis as well as mutagenesis. Dr. qxd 11/14/01 10:36 AM Page 27 DNA Structure, Replication, and Repair Answers 27 ified not to grow in the absence of histidine because of a mutation in one of the genes for the biosynthesis of histidine.

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