By Jose Rueff, António Sebastião Rodrigues
This quantity discusses the most recent developments and applied sciences utilized in melanoma drug resistance learn. Cancer Drug Resistance: Overviews and strategies contains chapters that disguise issues akin to: learning the mechanics of resistance to DNA destructive healing medications; reports to delineate the position of efflux transporters; expression of drug transporters; resistance to particular treatments in breast melanoma; the function of microRNAs in present pancreatic melanoma therapy; and melanoma exosomes as mediators of drug resistance or scientific and molecular tools in drug improvement and using bioinformatics within the administration of melanoma drug resistance information. Written within the hugely winning Methods in Molecular Biology series layout, chapters comprise overviews of the most matters in melanoma drug resistance and the respective mechanisms, in addition to introductions to their respective issues, lists of the required fabrics and reagents, step by step, without problems reproducible laboratory protocols, and tips about troubleshooting and warding off identified pitfalls.
Authoritative and functional, Cancer Drug Resistance: Overviews and Methods, is a precious source to researchers, oncobiologists and scientific oncologists or somebody else who's drawn to the research of melanoma and its drug resistances.
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Additional info for Cancer Drug Resistance: Overviews and Methods
In one approach , a technetium-labeled P-gp substrate, 99mTcsestamibi (25–30 mCi per patient), was injected intravenously. Planar scintigraphic images of known tumor sites were taken after 10 min and 2 h to determine the rate of clearance. The same procedure was repeated after administration of the tariquidar, an inhibitor of ABC transporters, in order to determine its effect on 99m Tc-sestamibi uptake. The tumor-to-background ratios were calculated for all tumor sites by measurement of sestamibi uptake within the visualized portion of the tumor, and comparing it with that of adjacent tissues that were without tumor involvement .
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50. 51. 52. 53. 54. 55. 56. 57. 58. 17 Gaspar JF (2010) The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk. Oncol Rep 24:1079–1085 Silva SN, Tomar M, Paulo C, Gomes BC, Azevedo AP, Teixeira V, Pina JE, Rueff J, Gaspar JF (2010) Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. Cancer Epidemiol 34:85–92 Silva SN, Gomes BC, Rueff J, Gaspar JF (2011) DNA repair perspectives in thyroid and breast cancer: the role of DNA repair polymorphisms.