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NEWTON, A. , 2001 Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101: 2353-2364. , L. SEGALAT and J. M. KAPLAN, 1999 Serotonin inhibition of synaptic transmission: Goa decreases the abundance of UNC-13 at release sites. Neuron 24: 231-242. , and M. I. SIMON , 1998 Genetic analysis of mammalian G-protein signalling. Oncogene 17: 1375-1381. P A R K , E. , and H. R. HO R V I T Z, 1986 Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.

In this study, we show that sgs-1 is an essential gene and that sgs-1 is involved in behaviors such as locomotion and pharyngeal pumping. To identify new residues in sgs-1 that are important for normal response to G␣s, we performed a genetic screen for suppressors of the activated G␣s-induced neuronal degeneration. In total, we identified 14 residues in sgs-1 that can be mutated to suppress the neuronal degeneration. Ten of these residues are located in the catalytic domains of sgs-1, but four mutations in the transmembrane domains were also found.

RICHMOND, J. , W. S. DAVIS and E. M. JORGENSEN, 1999 UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci 2: 959-964. RICHMOND, J. , R. M. WEIMER and E. M. JORGENSEN, 2001 An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature 412: 338-341. R IDDLE , D. , T. BLUMENTHAL , B. J. MEYER and J. R. PRIESS , 1997 C. elegans II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. , J. G. CRUMP, A. SAGASTI and C. I. BARGMANN, 1998 The Ga protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C.

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